The Role of MicroRNAs Regulated Breast Cancer Stem Cells in the Pathogenesis, Prognosis and Aggressiveness of Breast Cancer

Breast cancer is a leading cause of related death among women worldwide and it complex disease characterized by its heterogeneity. The heterogenous characteristic the breast responsible for aggressiveness treatment resistance. stem cells (BCSCs) are population with increased propensity proliferation, differentiation, migration, invasion mammosphere formation resistance to treatment. They have ability initiate propagate share similarity normal in relation their expressions cell surface markers; Cluster Differentiation 44 positive (CD44+), 24 negative/low (CD24-/low) Alkaline dehydrogenase 1 (ALDH1).
 MicroRNAs (miRNAs) RNA silencing post-transcriptional regulation gene expression. control expression acting as oncogenes or tumor suppressor genes. epigenetic mechanisms used miRNAs cancer, this can be targeted reverse progression. This review aims provide an overview pathogenic mechanism microRNA’s on controlling prognosis disease. done highlighting regulatory miRNA BCSCs.
 Dysregulation upregulated were identified (BCSCs), including miR-10b, miR-21, miR-155, miR-181, miR-183, miR-210 miR-221/222, downregulated BCSCs include Let-7, miR-22, miR-30e, miR-31, miR-103/107, miR-200, miR-205, miR-335, miR-449a, miR-519c, miR-600, miR-708, miR-760. Studies showed association between metastasis aggressiveness. noticed effect neovascularization, drug resistance, metastasis. predictive indicators determining following determine metastatic efficient targeting identification cells. systematic literature at providing insight into potential roles microRNA oncology especially cancers. data study obtained from Medline OvidSP, includes PubMed US National Library Medicine search was through University Bristol services. microRNAs will highlight dysregulation oncogenic regulated pathogenesis, prognosis, cancer. We further discuss biogenesis miRNAs, BCSCs, then summarize BCSCs.